Anti-Mouse CD90.2 FITC

Catalog Number : 03012-50

Description

The 30-H12 monoclonal antibody specifically binds to mouse CD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.

The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.

Additional Information

Clone:	30-H12
Format:	FITC
Applications:	FC
Reactivity:	Mouse
Isotype:	Rat IgG2b
Research Interest:	Adaptive Immunity
Cell Type:	T Cells
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Ledbetter, J. A., & Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens. Immunological reviews, 47(1), 63-90. Radrizzani, M., Carminatti, H., Pivetta, O. H., & Vargas, V. P. (1995). Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research, 42(2), 220-227. Seaman, W. E., Wofsy, D., Greenspan, J. S., & Ledbetter, J. A. (1983). Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology, 130*(4), 1713-1718.

Availability: In stock

Size	Price	Qty
25 μg	$25.00
100 μg	$75.00

Additional 30-H12 Formats

Cat.No.	Format	Starting From
03012-50	FITC	$ 25.00
03012-77	PE-Cyanine7	$ 95.00
03012-80	APC	$ 65.00
03012-40	BG Violet 450	$ 75.00
03012-25	SAFIRE Purified	$ 100.00