Anti-Mouse CD90.2 BG Violet 450
Additional 30-H12 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 03012-50 | FITC | $ 25.00 |
| 03012-77 | PE-Cyanine7 | $ 95.00 |
| 03012-80 | APC | $ 65.00 |
| 03012-40 | BG Violet 450 | $ 75.00 |
| 03012-25 | SAFIRE Purified | $ 580.00 |
description
The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.
The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.
BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Additional Information
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Clone:
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30-H12
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Format:
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BG Violet 450
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2b
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | T Cells |
| Application: | FC |
| Clone: | 30-H12 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Ledbetter, J. A., & Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*. Immunological reviews, 47(1), 63-90. Radrizzani, M., Carminatti, H., Pivetta, O. H., & Vargas, V. P. (1995). Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research, 42(2), 220-227. Seaman, W. E., Wofsy, D., Greenspan, J. S., & Ledbetter, J. A. (1983). Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology, 130(4), 1713-1718. |