Anti-Mouse CD90.2 (Thy-1.2) SAFIRE Purified
Additional 30-H12 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 03012-50 | FITC | $ 25.00 |
| 03012-77 | PE-Cyanine7 | $ 95.00 |
| 03012-80 | APC | $ 65.00 |
| 03012-40 | BG Violet 450 | $ 75.00 |
| 03012-25 | SAFIRE Purified | $ 580.00 |
description
The 30-H12 monoclonal antibody specifically binds to Mouse CD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma.
The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.
Additional Information
|
Clone:
|
30-H12
|
|
Format:
|
SAFIRE Purified
|
|
Applications:
|
FC, FA
|
|
Reactivity:
|
Mouse
|
|
Isotype:
|
Rat IgG2b, kappa
|
| Research Interest: | Adaptive Immunity |
|---|---|
| Cell Type: | T Cells |
| Application: | FC, FA |
| Clone: | 30-H12 |
|
Preparation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
|
References:
|
Ledbetter, J. A., & Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*. Immunological reviews, 47(1), 63-90. Hathcock, K. (1991). T cell enrichment by cytotoxic elimination of B cells and accessory cells. Current protocols in immunology, 3-3. Nakashima, I. Z. U. M. I., Zhang, Y. H., Rahman, S. M., Yoshida, T. O. M. O. A. K. I., Isobe, K. L., Ding, L. N., ... & Taguchi, R. (1991). Evidence of synergy between Thy-1 and CD3/TCR complex in signal delivery to murine thymocytes for cell death. The Journal of Immunology, 147(4), 1153-1162. |