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Anti-Human CD40 SAFIRE Purified



Catalog Number : 02511-25

Description

The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.

Additional Information

Clone:
5C3
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity
Cell Type: B Cells, Dendritic Cells, NK and NKT Cells, Monocytes and Macrophages
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Schlossman, S. F. (1995). Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Barclay, A. N., Birkeland, M. L., Brown, M. H., Beyers, A. D., David, S. J., Somoza, C., & Williams, A. F. The Leukocyte Antigen Facts Book. 1993.Academic Prss, London.

Challa, A., Pound, J. D., Gordon, J., & Armitage, R. J. (1999). Epitope‐dependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B cells. Allergy54(6), 576-583.


Availability: In stock

Size Price Qty
50 ug
$120.00
500 ug
$360.00
Additional 5C3 Formats
Cat.No. Format Starting From
02511-50FITC $ 90.00
02511-25SAFIRE Purified $ 120.00
02511-80APC $ 155.00
02511-77PE-Cyanine7 $ 130.00