Anti-Human CD40 PE-Cyanine7
Additional 5C3 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 02511-50 | FITC | $ 335.00 |
| 02511-25 | SAFIRE Purified | $ 180.00 |
| 02511-80 | APC | $ 195.00 |
| 02511-77 | PE-Cyanine7 | $ 550.00 |
Catalog Number : 02511-77
description
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.
Additional Information
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Clone:
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5C3
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Format:
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PE-Cyanine7
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Adaptive Immunity, Innate Immunity |
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| Cell Type: | B Cells, Macrophage / Monocyte, NK and NKT Cells |
| Application: | FC |
| Clone: | 5C3 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Schlossman, S. F. (1995). Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press. Barclay, A. N., Birkeland, M. L., Brown, M. H., Beyers, A. D., David, S. J., Somoza, C., & Williams, A. F. The Leukocyte Antigen Facts Book. 1993.Academic Prss, London. Challa, A., Pound, J. D., Gordon, J., & Armitage, R. J. (1999). Epitope‐dependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B cells. Allergy, 54(6), 576-583. |