Anti-Mouse CD25 SAFIRE Purified

Grouped product items
Size Price Qty
100 μg
500 μg

Additional PC61.5 Formats

Cat.No. Format Starting From
07312-60 PE $ 60.00
07312-70 PerCP-Cyanine5.5 $ 90.00
07312-77 PE-Cyanine7 $ 70.00
07312-40 BG Violet 450 $ 90.00
07312-20 Purified $ 65.00
07312-25 SAFIRE Purified $ 120.00
07312-80 APC $ 75.00
07312-50 FITC $ 55.00
Catalog Number : 07312-25


The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.

The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.

Additional Information

SAFIRE Purified
Rat IgG1, lambda
Research Interest: Adaptive Immunity
Cell Type: B Cells, T Cells, T Regulatory Cells
Application: FC, FA, IHC, IP
Clone: PC61.5
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Phosphate-buffered aqueous solution, ph7.2.

Hayashi, T., Hasegawa, K., & Adachi, C. (2005). Elimination of CD4+ CD25+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB× NZW F1 mice. International journal of experimental pathology86(5), 289-296.

Lowenthal, J. W., Tougne, C., MacDonald, H. R., Smith, K. A., & Nabholz, M. (1985). Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone. The Journal of Immunology134(2), 931-939.

Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., ... & Feng, Z. H. (2007). Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Research67(9), 4346-4352.

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