Anti-Mouse CD25 APC
Additional PC61.5 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 07312-60 | PE | $ 60.00 |
| 07312-70 | PerCP-Cyanine5.5 | $ 90.00 |
| 07312-77 | PE-Cyanine7 | $ 70.00 |
| 07312-40 | BG Violet 450 | $ 90.00 |
| 07312-20 | Purified | $ 65.00 |
| 07312-25 | SAFIRE Purified | $ 120.00 |
| 07312-80 | APC | $ 75.00 |
| 07312-50 | FITC | $ 55.00 |
description
The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.
The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.
Additional Information
Clone: | PC61.5 |
Format: | APC |
Applications: | FC |
Reactivity: | Mouse |
Isotype: | Rat IgG1, lambda |
| Research Interest: | Adaptive Immunity |
|---|---|
| Cell Type: | B Cells, T Cells, T Regulatory Cells |
| Application: | FC |
| Clone: | PC61.5 |
Preparation: | The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Formulation: | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
References: | Hayashi, T., Hasegawa, K., & Adachi, C. (2005). Elimination of CD4+ CD25+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB× NZW F1 mice. International journal of experimental pathology, 86(5), 289-296. Lowenthal, J. W., Tougne, C., MacDonald, H. R., Smith, K. A., & Nabholz, M. (1985). Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone. The Journal of Immunology, 134(2), 931-939. Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., ... & Feng, Z. H. (2007). Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Research, 67(9), 4346-4352. |