Anti-Human CD8a PE
The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.
OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.
|Research Interest:||Adaptive Immunity|
|Cell Type:||T Cells, NK and NKT Cells, Dendritic Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., ... & Terhorst, C. (1998). The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature, 395(6701), 462-469.
Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., & Chess, L. (1980). Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation. The Journal of Immunology, 125(6), 2402-2408.
Campanelli, R., Palermo, B., Garbelli, S., Mantovani, S., Lucchi, P., Necker, A., ... & Giachino, C. (2002). Human CD8 co–receptor is strictly involved in MHC–peptide tetramer–TCR binding and T cell activation. International immunology, 14(1), 39-44.