Anti-Mouse Granzyme B PE
Catalog Number : 72212-60
description
The NGZB monoclonal antibody specifically reacts with mouse Granzyme B, a protease found in the granules of NK and killer T cells. Granzyme B is utilized by cytotoxic T cells to rapidly induce target cell death through the mannose 6-phosphate death receptor. The NGZB antibody does not recognize human Granzyme B.
Additional Information
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Clone:
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NGZB
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Format:
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PE
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Applications:
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FC
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2a, kappa
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| Research Interest: | Cytokines & Growth Factors |
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| Cell Type: | NK and NKT Cells, T Cells |
| Application: | FC |
| Clone: | NGZB |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Smyth, M. J., & Trapani, J. A. (1995). Granzymes: exogenous porteinases that induce target cell apoptosis. Immunology today, 16(4), 202-206. Kapp, J. A., Honjo, K., Kapp, L. M., yan Xu, X., Cozier, A., & Bucy, R. P. (2006). TCR transgenic CD8+ T cells activated in the presence of TGFβ express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. International immunology, 18(11), 1549-1562. |