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Anti-Mouse CD49b (Integrin alpha 2) SAFIRE Purified



Catalog Number : 11512-25

Description

The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1). VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.

Additional Information

Clone:
HMa2
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse
Isotype:
Armenian Hamster IgG
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: T Cells, Monocytes and Macrophages, NK and NKT Cells
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Arase, H., Saito, T., Phillips, J. H., & Lanier, L. L. (2001). Cutting edge: the mouse NK cell-associated antigen recognized by DX5 moncoclonal antibody is CD49b (α2 integrin, very late antigen-2). The Journal of Immunology167(3), 1141-1144.

Miyake, S., Sakurai, T., Okumura, K., & Yagita, H. (1994). Identification of collagen and laminin receptor integrins on murine T lymphocytes. European journal of immunology24(9), 2000-2005.

Noto, K., Kato, K., Okumura, K., & Yagita, H. (1995). Identification and functional characterization of mouse CD29 with a mAb. International immunology7(5), 835-842.


Availability: In stock

Size Price Qty
50 ug
$110.00
500 ug
$330.00
Additional HMa2 Formats
Cat.No. Format Starting From
11512-25SAFIRE Purified $ 110.00