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Anti-Mouse CD18 SAFIRE Purified



Catalog Number : 10212-25

Description

The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein. CD18 is expressed on all leukocytes with the highest density by NK and T cells. CD18 forms LFA-1 with CD11a, Mac-1 with CD11b and gp150/95 with CD11c. Through these interactions, CD18 has an important role in cellular adhesion. The M18/2 antibody is reported to stimulate Mac-1 and LFA-1 adhesion to their ligands and block tumor cell metastasis.

Additional Information

Clone:
M18/2
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest: Angiogenesis
Cell Type: T Cells, NK and NKT Cells
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Driessens, M. H., Van Hulten, P., Zuurbier, A., La Riviere, G., & Roos, E. (1996). Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1,-2, and-3 are distinct. Journal of leukocyte biology60(6), 758-765.

Zahalka, M. A., & Naor, D. (1994). β2-lntegrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness. International immunology6(6), 917-924.

Isobe, M., Yagita, H., Okumura, K., & Ihara, A. (1992). Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science,255(5048), 1125-1127.


Availability: In stock

Size Price Qty
50 ug
$100.00
500 ug
$310.00
Additional M18/2 Formats
Cat.No. Format Starting From
10212-25SAFIRE Purified $ 100.00