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Anti-Human IFN gamma FITC



Catalog Number : 80811-50

Description

The 4S.B3 is a neutralizing antibody that binds with the human Interferon-gamma (IFN-γ) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-γ plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-α, to inhibit proliferation of normal and transformed cells. IFN- γ is the primary cytokine that defines Th-1 cells.

The biological activity of IFN-γ is not affected by glycosylation

Additional Information

Clone:
4S.B3
Format:
FITC
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Innate Immunity, Adaptive Immunity, Cytokines & Growth Factors
Cell Type: Th1 cells, NK and NKT Cells, T Cells
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Meager, A. (1987). Antibodies against interferons: Characterization of interferons and immunoassays. Lymphockies and Interferons. A Practical Approach. Clemens, MJ, AG Morris, and AJH Gearing, eds. IRL Press Ltd. Oxford, 105.

Prussin, C., & Metcalfe, D. D. (1995). Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. Journal of immunological methods188(1), 117-128.

Jason, J., & Larned, J. (1997). Single-cell cytokine profiles in normal humans: comparison of flow cytometric reagents and stimulation protocols. Journal of immunological methods207(1), 13-22.


Availability: In stock

Size Price Qty
25 tests
$110.00
50 ug
$130.00
100 ug
$220.00
Additional 4S.B3 Formats
Cat.No. Format Starting From
80811-50FITC $ 110.00
80811-77PE-Cyanine7 $ 140.00
80811-80APC $ 120.00
80811-60PE $ 110.00