Anti-Human IFN gamma FITC
Catalog Number : 80811-50
description
The 4S.B3 is a neutralizing antibody that binds with the human Interferon-gamma (IFN-γ) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-γ plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-α, to inhibit proliferation of normal and transformed cells. IFN- γ is the primary cytokine that defines Th-1 cells.
The biological activity of IFN-γ is not affected by glycosylation
Additional Information
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Clone:
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4S.B3
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Format:
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FITC
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Innate Immunity, Adaptive Immunity, Cytokines & Growth Factors |
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| Cell Type: | Th1 cells, NK and NKT Cells, T Cells |
| Application: | FC |
| Clone: | 4S.B3 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Meager, A. (1987). Antibodies against interferons: Characterization of interferons and immunoassays. Lymphockies and Interferons. A Practical Approach. Clemens, MJ, AG Morris, and AJH Gearing, eds. IRL Press Ltd. Oxford, 105. Prussin, C., & Metcalfe, D. D. (1995). Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. Journal of immunological methods, 188(1), 117-128. Jason, J., & Larned, J. (1997). Single-cell cytokine profiles in normal humans: comparison of flow cytometric reagents and stimulation protocols. Journal of immunological methods, 207(1), 13-22. |