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Anti-Human CD62L (L-Selectin) SAFIRE Purified



Catalog Number : 04731-25

Description

The DREG-56 monoclonal antibody specifically reacts with human CD62L, also known as L-selectin and LECAM-1. It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). CD62L is expressed on monocytes, NK cells, neutrophils, granulocytes, and subsets of T and B cells. It is reported that the DREG-56 antibody inhibits the binding of lymphocytes to HEV tissue in frozen peripheral tissue.

Additional Information

Clone:
DREG-56
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: B Cells, T Cells, NK and NKT Cells, Monocytes and Macrophages
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Schlossman, S. F. (1995). Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Kishimoto, T. K., Jutila, M. A., & Butcher, E. C. (1990). Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proceedings of the National Academy of Sciences87(6), 2244-2248.

Kishimoto, T. K., Warnock, R. A., Jutila, M. A., Butcher, E. C., Lane, C., Anderson, D. C., & Smith, C. W. (1991). Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood78(3), 805-811.


Availability: In stock

Size Price Qty
50 ug
$130.00
500 ug
$385.00
Additional DREG-56 Formats
Cat.No. Format Starting From
04731-25SAFIRE Purified $ 130.00
04731-60PE $ 100.00