Anti-Human CD32 APC
Additional 6C4 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 04411-25 | SAFIRE Purified | $ 215.00 |
| 04411-80 | APC | $ 265.00 |
Catalog Number : 04411-80
description
The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB. From alternative mRNA splicing, 6 isoforms of CD32 have been reported. CD32 is a 40 kDA polymorphic transmembrane glycoprotein expressed on monocytes, macrophages, graulocytes, B cells, and platelets. The receptor has low affinity toward IgG and is involved in immunomodulation, phagocytosis, and the inflammation response. The 6C4 antibody in a rosette blocking assay is reported to inhibit Ig binding
Additional Information
|
Clone:
|
6C4
|
|
Format:
|
APC
|
|
Applications:
|
FC
|
|
Reactivity:
|
Human
|
|
Isotype:
|
Mouse IgG1, kappa
|
| Research Interest: | Inflammation |
|---|---|
| Cell Type: | B Cells, Macrophage / Monocyte, NK and NKT Cells |
| Application: | FC |
| Clone: | 6C4 |
|
Preparation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
VELY, F., GRUEL, N., MONCUIT, J., COCHET, O., ROUARD, H., DARE, S., ... & TEILLAUD, J. L. (1997). A new set of monoclonal antibodies against human FcγRII (CD32) and FcγRIII (CD16): characterization and use in various assays. Hybridoma, 16(6), 519-528. Liebert, M. A. (1997). 6C4, 2B2, 3D3. Hybridoma, 16(6). Bouhlal, H., Martinvalet, D., Teillaud, J. L., Fridman, C., Kazatchkine, M. D., Bayry, J., ... & Kaveri, S. V. (2014). Natural Autoantibodies to Fcγ Receptors in Intravenous Immunoglobulins. Journal of clinical immunology, 1-8. |