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Anti-Human CD32 SAFIRE Purified



Catalog Number : 04411-25

Description

The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB. From alternative mRNA splicing, 6 isoforms of CD32 have been reported. CD32 is a 40 kDA polymorphic transmembrane glycoprotein expressed on monocytes, macrophages, graulocytes, B cells, and platelets. The receptor has low affinity toward IgG and is involved in immunomodulation, phagocytosis, and the inflammation response. The 6C4 antibody in a rosette blocking assay is reported to inhibit Ig binding

Additional Information

Clone:
6C4
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest: Inflammation
Cell Type: B Cells, NK and NKT Cells, Monocytes and Macrophages
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

VELY, F., GRUEL, N., MONCUIT, J., COCHET, O., ROUARD, H., DARE, S., ... & TEILLAUD, J. L. (1997). A new set of monoclonal antibodies against human FcγRII (CD32) and FcγRIII (CD16): characterization and use in various assays. Hybridoma16(6), 519-528.

Liebert, M. A. (1997). 6C4, 2B2, 3D3. Hybridoma16(6).

Bouhlal, H., Martinvalet, D., Teillaud, J. L., Fridman, C., Kazatchkine, M. D., Bayry, J., ... & Kaveri, S. V. (2014). Natural Autoantibodies to Fcγ Receptors in Intravenous Immunoglobulins. Journal of clinical immunology, 1-8.


Availability: In stock

Size Price Qty
50 ug
$120.00
500 ug
$385.00
Additional 6C4 Formats
Cat.No. Format Starting From
04411-25SAFIRE Purified $ 120.00
04411-80APC $ 155.00