Anti-Mouse CD140b (PDGF Receptor b) SAFIRE Purified

Grouped product items
Size Price Qty
100ug
$220.00

Additional APB5 Formats

Cat.No. Format Starting From
12522-25 SAFIRE Purified $ 220.00
Catalog Number : 12522-25

description

The APB5 monoclonal antibody specifically binds to the mouse CD140b molecule, otherwise known as the Platelet-Derived Growth Factor (PDGF) Receptor beta chain. CD140b is a receptor tyrosine kinase expressed on embryonic tissue and adult mesenchymal-derived cells. The APB5 antibody is reported to block the binding of PDGF-BB to the PDGF receptor.

Additional Information

Clone:
APB5
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest: Stem Cell Research
Cell Type: Stem Cells
Application: FC, FA
Clone: APB5
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Jo, N., Mailhos, C., Ju, M., Cheung, E., Bradley, J., Nishijima, K., ... & Shima, D. T. (2006). Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. The American journal of pathology,168(6), 2036-2053.

Sano, H., Sudo, T., Yokode, M., Murayama, T., Kataoka, H., Takakura, N., ... & Kita, T. (2001). Functional blockade of platelet-derived growth factor receptor-β but not of receptor-α prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E–deficient mice. Circulation103(24), 2955-2960.

Soriano, P. (1994). Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes & development8(16), 1888-1896.

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