Anti-Mouse B7-H4 SAFIRE Purified
Additional 188 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 86612-25 | SAFIRE Purified | $ 300.00 |
Catalog Number : 86612-25
description
The 188 monoclonal antibody binds to mouse B7-H4, a newly discovered member of the B7 family involved with the negative regulation of T cell immunity. B7-H4 is a type I membrane glycoprotein also known as B7S1, B7X, and VCTN1. Its role in tumor progression may be to protect precancerous cells from the surveillance of the immune system. Further studies are being conducted to determine the exact B7-H4 ligand. It is reported that the H74 antibody binds to mouse B7-H4 transfected cells and not spleen cells.
Additional Information
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Clone:
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188
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Format:
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SAFIRE Purified
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Applications:
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FC, FA
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Reactivity:
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Mouse
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Isotype:
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Rat IgG2b, kappa
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| Research Interest: | Adaptive Immunity |
|---|---|
| Application: | FC, FA |
| Clone: | 188 |
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Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Yi, K. H., & Chen, L. (2009). Fine tuning the immune response through B7‐H3 and B7‐H4. Immunological reviews, 229(1), 145-151. Chen, Y., Yang, C., Xie, Z., Zou, L., Ruan, Z., Zhang, X., ... & Wu, Y. (2006). Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells. Kidney international, 70(12), 2092-2099. Kamimura, Y., Kobori, H., Piao, J., Hashiguchi, M., Matsumoto, K., Hirose, S., & Azuma, M. (2009). Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses. Biochemical and biophysical research communications, 389(2), 349-353. |