Anti-Mouse B7-H4 SAFIRE Purified

Grouped product items
SizePrice Qty
50 ug
$175.00

Additional 188 Formats

Cat.No.FormatStarting From
86612-25SAFIRE Purified$ 175.00
Catalog Number : 86612-25

description

The 188 monoclonal antibody binds to mouse B7-H4, a newly discovered member of the B7 family involved with the negative regulation of T cell immunity. B7-H4 is a type I membrane glycoprotein also known as B7S1, B7X, and VCTN1. Its role in tumor progression may be to protect precancerous cells from the surveillance of the immune system. Further studies are being conducted to determine the exact B7-H4 ligand. It is reported that the H74 antibody binds to mouse B7-H4 transfected cells and not spleen cells.

Additional Information

Clone:
188
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Mouse
Isotype:
Rat IgG2b, kappa
Research Interest:Adaptive Immunity
Application:FC, FA
Clone:188
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Yi, K. H., & Chen, L. (2009). Fine tuning the immune response through B7‐H3 and B7‐H4. Immunological reviews229(1), 145-151.

Chen, Y., Yang, C., Xie, Z., Zou, L., Ruan, Z., Zhang, X., ... & Wu, Y. (2006). Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells. Kidney international70(12), 2092-2099.

Kamimura, Y., Kobori, H., Piao, J., Hashiguchi, M., Matsumoto, K., Hirose, S., & Azuma, M. (2009). Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses. Biochemical and biophysical research communications389(2), 349-353.

© BioGems International, Inc. All rights reserved.