Anti-Mouse NK1.1 (CD161) APC
The PK136 monoclonal antibody is specific for the mouse NK1.1, a receptor from the killer cell lectin-like receptor (KLR) family. Nk1.1 is an antigen encoded by the Klrb1c/NKR-P1C gene expressed by the natural killer cells of some selected strains of mice (C57BL, FVB/N, NZB) and encoded by the Klrb1b/NKR-P1B gene expressed on Swiss NIH and SJL mice. Pk136 binds to an epitope common to NKR-P1B and NKR-P1C.
The Klrb1 is a family of type II transmembrane C-type lectin receptors. Klrb1c activates the NK-cell cytotoxicity, while Klrb1b inhibits it.
PK136 is useful in defining the NK cells and the rare population of NK-T lymphocytes and specific cultured monocytes.
Mouse IgG2a, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||NK and NKT Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Koo, G. C., & PEPPARD, J. R. (1984). Establishment of monoclonal anti-Nk-1.1 antibody. Hybridoma, 3(3), 301-303.
Carlyle, J. R., Martin, A., Mehra, A., Attisano, L., Tsui, F. W., & Zúñiga-Pflücker, J. C. (1999). Mouse NKR-P1B, a novel NK1. 1 antigen with inhibitory function. The Journal of Immunology, 162(10), 5917-5923.
Karlhofer, F. M., & Yokoyama, W. M. (1991). Stimulation of murine natural killer (NK) cells by a monoclonal antibody specific for the NK1. 1 antigen. IL-2-activated NK cells possess additional specific stimulation pathways. The Journal of Immunology, 146(10), 3662-3673.