Anti-Mouse IL-4 APC
The 11B11 monoclonal antibody specifically reacts with mouse 14 kDa cytokine IL-4, expressed by the activated NKT cells and mast cells. IL-4 is species-specific and stimulates the proliferation and differentiation of B lymphocytes. It upregulates the expression of IgE receptors and class II MHC antigen.
The 11B11 antibody neutralizes the IL-4 cytokine.
Rat IgG1, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||T Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Abrams, John S. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. John Wiley & Sons, Inc., 1995.
Ohara, J., and W. E. Paul. "Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1." Nature 315.6017 (1985): 333.
Haak-Frendscho, M., Brown, J. F., Iizawa, Y. U. J. I., Wagner, R. D., & Czuprynski, C. J. (1992). Administration of anti-IL-4 monoclonal antibody 11B11 increases the resistance of mice to Listeria monocytogenes infection. The Journal of Immunology, 148(12), 3978-3985.