Anti-Mouse Foxp3 APC

Grouped product items
SizePrice Qty
25 ug
$210.00
100 ug
$340.00

Additional MF23 Formats

Cat.No.FormatStarting From
83812-80APC$ 210.00
83812-60PE$ 135.00
Catalog Number : 83812-80

description

The MF23 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression. Mutations of Foxp3 result in the “scurfy” mice phenotype. It is reported that the MF23 antibody recognizes an epitope between 1-87 amino acids in the N-terminal domain of mouse Foxp3.

Additional Information

Clone:
MF23
Format:
APC
Applications:
FC
Reactivity:
Mouse
Isotype:
Rat IgG2b
Research Interest:Adaptive Immunity
Cell Type:T Cells, T Regulatory Cells
Application:FC
Clone:MF23
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Ono, M., Yaguchi, H., Ohkura, N., Kitabayashi, I., Nagamura, Y., Nomura, T., ... & Sakaguchi, S. (2007). Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature446(7136), 685-689.

Touitou, V., Daussy, C., Donnou, S., Galand, C., Bodaghi, B., Salomon, B. L., ... & Sautès-Fridman, C. Naturally Occurring CD4 CD25 Foxp3 Regulatory T Cells Participate in but do not Govern Immune Escape in Primary Intraocular Lymphoma.

Hori, S., Nomura, T., & Sakaguchi, S. (2003). Control of regulatory T cell development by the transcription factor Foxp3. Science299(5609), 1057-1061.

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