Anti-Human CD272 (BTLA) Biotin
Catalog Number : 24811-30
description
The MIH26 monoclonal antibody specifically reacts with human CD272, the human and B and T lymphocyte attenuator (BTLA). It is expressed on macrophage, dendritic, NK, NKT, B, and T cells. CD272 (BTLA) is an inhibitory receptor that inhibits T cell proliferation after binding with its ligand, the herpes virus entry mediator (HVEM). It is in the CD28-like family of receptors and is structurally similar to CTLA-4 and PD-1.
Additional Information
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Clone:
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MIH26
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Format:
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Biotin
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Applications:
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FC
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Reactivity:
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Human
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Isotype:
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Mouse IgG2a
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | B Cells, Macrophage / Monocyte, T Cells, Dendritic Cells |
| Application: | FC |
| Clone: | MIH26 |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Otsuki, N., Kamimura, Y., Hashiguchi, M., & Azuma, M. (2006). Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. Biochemical and biophysical research communications, 344(4), 1121-1127. Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., ... & Murphy, K. M. (2003). BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nature immunology, 4(7), 670-679. Sedy, J. R., Gavrieli, M., Potter, K. G., Hurchla, M. A., Lindsley, R. C., Hildner, K., ... & Murphy, K. M. (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nature immunology, 6(1), 90-98. |