Anti-Human CD25 APC
The BC96 monoclonal antibody specifically reacts with the 55 kDa type I transmembrane glycoprotein known as the interleukin-2 receptor α (IL-2R α, also known as CD25). CD25 is expressed by the early progenitors of T and B lymphocytes lineage, and by activated mature T and B lymphocytes. CD25 is a low affinity interleukin-2 receptor, but its association with the IL-2 receptor β chain (CD122) and the common γ chain (CD 132) results in a high affinity IL-2R complex. CD25 plays an important role in B and T cell proliferation, differentiation, and activation.
Mouse IgG1, kappa
|Research Interest:||Adaptive Immunity|
|Cell Type:||B Cells, T Cells, T Regulatory Cells|
|Protein Cross Reactivity:||Baboon, Chimpanzee, Cynomolgus, Rhesus|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Zhang, B., Zhang, X., Tang, F. L., Zhu, L. P., Liu, Y., & Lipsky, P. E. (2008). Clinical significance of increased CD4+ CD25− Foxp3+ T cells in patients with new-onset systemic lupus erythematosus. Annals of the rheumatic diseases,67(7), 1037-1040.
Chapel, A., Bensussan, A., Vilmer, E., & Dormont, D. (1992). Differential human immunodeficiency virus expression in CD4+ cloned lymphocytes: from viral latency to replication. Journal of virology, 66(6), 3966-3970.