Anti-Human CD223 (LAG3) PE-Cyanine7

Grouped product items
SizePrice Qty
25 tests
$160.00
100 tests
$415.00

Additional 3DS223H Formats

Cat.No.FormatStarting From
25311-80APC$ 170.00
25311-50FITC$ 160.00
25311-60PE$ 130.00
25311-77PE-Cyanine7$ 160.00
Catalog Number : 25311-77

description

The 3DS223H monoclonal antibody recognized human CD223, a 70 kDa glycoprotein that is also known as the Lymphocyte Activation Gene 3 (LAG-3). CD223 is an immune checkpoint receptor in the Ig superfamily and its main ligand is MHC class II, which it binds with higher affinity than CD4. It is reported to play a role in Treg suppressive activity and is involved in the maturation and activation of dendritic cells.

Additional Information

Clone:
3DS223H
Format:
PE-Cyanine7
Applications:
FC
Reactivity:
Human
Isotype:
Mouse IgG1, kappa
Research Interest:Adaptive Immunity
Cell Type:T Cells, NK and NKT Cells
Application:FC
Clone:3DS223H
Preparation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Anvari, S., Grimbergen, A., Davis, C. M., & Makedonas, G. (2017). Protein transport inhibitors downregulate the expression of LAG-3 on regulatory T cells. Journal of immunological methods447, 47-51.

Jiang, Z., Jiang, X., Chen, S., Lai, Y., Wei, X., Li, B., ... & Liu, Q. (2017). Anti-GPC3-CAR T cells suppress the growth of tumor cells in patient-derived xenografts of hepatocellular carcinoma. Frontiers in immunology7, 690.

Long, A. H., Highfill, S. L., Cui, Y., Smith, J. P., Walker, A. J., Ramakrishna, S., ... & Mackall, C. L. (2016). Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas. Cancer immunology research, canimm-0230.

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