Anti-Human CD314 (NKG2D) PE
Catalog Number : 35311-60
The 1D11 monoclonal antibody specifically binds to human CD314 (NKG2D), a transmembrane C-type lectin-like receptor. CD314 recognizes proteins that appear on the surface of NK cells and T cell subtypes. CD314 is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress. The 1D11 antibody is reported to block the binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells.
Mouse IgG1, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||NK and NKT Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Domogala, A., Blundell, M., Thrasher, A., Lowdell, M. W., Madrigal, J. A., & Saudemont, A. (2017). Natural killer cells differentiated in vitro from cord blood CD34+ cells are more advantageous for use as an immunotherapy than peripheral blood and cord blood natural killer cells. Cytotherapy, 19(6), 710-720.
Warren, H. S. (2005). The eighth human leucocyte differentiation antigen (HLDA8) workshop: Natural killer cell section report. Cellular immunology, 236(1-2), 17-20.
Burt, B. M., Plitas, G., Nguyen, H. M., Stableford, J. A., Bamboat, Z. M., & DeMatteo, R. P. (2008). Circulating HLA-DR+ natural killer cells have potent lytic ability and weak antigen-presenting cell function. Human immunology, 69(8), 469-474.