Anti-Human CD16 PE
Additional 3G8 Formats
|08221-25||SAFIRE Purified||$ 220.00|
Catalog Number : 08221-60
The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII). CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed exclusively on neutrophils.
Mouse IgG1, kappa
|Research Interest:||Innate Immunity|
|Cell Type:||Macrophage / Monocyte, NK and NKT Cells|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Choi, E. I., Wang, R., Peterson, L., Letvin, N. L., Reimann, K. A. (2008). Use of an anti‐CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques. Immunology, 124(2), 215-222.
Perussia, B. I. C. E., & Trinchieri, G. I. O. R. G. I. O. (1984). Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells. The Journal of Immunology, 132(3), 1410-1415.
Vossebeld, P. J., Homburg, C. H., Roos, D., & Verhoeven, A. J. (1997). The anti-FcγRIII mAb 3G8 induces neutrophil activation via a cooperative action of FcγRIIIb and FcγRIIa. The international journal of biochemistry & cell biology,29(3), 465-473.