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Anti-Mouse TCR beta Purified



Catalog Number : 89612-20

Description

The H57-597 monoclonal antibody is specific for the beta chain of the mouse T cell Receptor (TCR). The crosslinking induces activation and proliferation of T cells, as a plate-bound or a soluble H57-597, or the plate-bound antibody can induce apoptosis, based on assay conditions. The beta chain of the TCR can combine with the alpha chain of the receptor to produce the alpha-beta TCR, which is expressed by the NKT cells, by the NK1.1+ thymocytes and most of the T cells. The beta chain does not react with the gamma-delta TCR-bearing cells, expressed by a small number of T cells.

This antibody can be used as a phenotypic marker for the TCR beta expressing cells or for the functional purpose of TCR-mediated cell activation or apoptosis.

Additional Information

Clone
H57-597
Format:
Purified
Applications
FC, FA, IHC, IF, IP
Reactivity
Mouse
Isotype:
Armenian Hamster IgG
Research Interest: Adaptive Immunity
Cell Type: T Cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Kubo, R. T., Born, W., Kappler, J. W., Marrack, P., & Pigeon, M. (1989). Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. The Journal of Immunology142(8), 2736-2742.

Gascoigne, N. R. (1990). Transport and secretion of truncated T cell receptor beta-chain occurs in the absence of association with CD3. Journal of Biological Chemistry265(16), 9296-9301.

Kruisbeek, A. M., Shevach, E., & Thornton, A. M. (2004). Proliferative assays for T cell function. Current Protocols in Immunology, 3-12.

Saint-Ruf, C., Panigada, M., Azogui, O., Debey, P., von Boehmer, H., & Grassi, F. (2000). Different initiation of pre-TCR and γδTCR signalling. Nature,406(6795), 524-527.


Availability: In stock

Size Price Qty
100 μg
$80.00
Additional H57-597 Formats
Cat.No. Format Starting From
89612-70PerCP-Cyanine5.5 $ 85.00
89612-40BG Violet 450 $ 80.00
89612-20Purified $ 80.00
89612-50FITC $ 35.00
89612-80APC $ 65.00