Anti-Mouse TCR beta APC

Catalog Number : 89612-80

Description

The H57-597 monoclonal antibody is specific for the beta chain of the mouse T cell Receptor (TCR). The crosslinking induces activation and proliferation of T cells, as a plate-bound or a soluble H57-597, or the plate-bound antibody can induce apoptosis, based on assay conditions. The beta chain of the TCR can combine with the alpha chain of the receptor to produce the alpha-beta TCR, which is expressed by the NKT cells, by the NK1.1+ thymocytes and most of the T cells. The beta chain does not react with the gamma-delta TCR-bearing cells, expressed by a small number of T cells.

This antibody can be used as a phenotypic marker for the TCR beta expressing cells or for the functional purpose of TCR-mediated cell activation or apoptosis.

Additional Information

Clone:	H57-597
Format:	APC
Applications:	FC
Reactivity:	Mouse
Isotype:	Armenian Hamster IgG
Research Interest:	Adaptive Immunity
Cell Type:	T Cells
Preparation:	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:	Kubo, R. T., Born, W., Kappler, J. W., Marrack, P., & Pigeon, M. (1989). Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. The Journal of Immunology, 142(8), 2736-2742. Gascoigne, N. R. (1990). Transport and secretion of truncated T cell receptor beta-chain occurs in the absence of association with CD3. Journal of Biological Chemistry, 265(16), 9296-9301. Kruisbeek, A. M., Shevach, E., & Thornton, A. M. (2004). Proliferative assays for T cell function. Current Protocols in Immunology, 3-12. Saint-Ruf, C., Panigada, M., Azogui, O., Debey, P., von Boehmer, H., & Grassi, F. (2000). Different initiation of pre-TCR and γδTCR signalling. Nature,406(6795), 524-527.

Availability: In stock

Size	Price	Qty
25 μg	$65.00
100 μg	$160.00

Additional H57-597 Formats

Cat.No.	Format	Starting From
89612-70	PerCP-Cyanine5.5	$ 85.00
89612-40	BG Violet 450	$ 80.00
89612-20	Purified	$ 80.00
89612-50	FITC	$ 35.00
89612-80	APC	$ 65.00