Creating Value for Life Science Research!


Get a Free Sample of this product!
shopping cart image

Anti-Mouse CD4 PE-Cyanine7



Catalog Number : 06122-77

Description

The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck).

Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.

product image
C57BI/6 splenocytes were stained with PE-Cy7 RM4-5 with relevant isotype control in Red.
product image

Additional Information

Clone
RM4-5
Format:
PE-Cyanine7
Applications
FC
Reactivity
Mouse
Isotype:
Rat IgG2a, kappa
Research Interest: Adaptive Immunity
Cell Type: Monocytes and Macrophages, T Cells, Treg cells, Th17 cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Shevach, E. M. (2000). Regulatory T cells in autoimmmunity*. Annual review of immunology18(1), 423-449.

Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. J., & Shortman, K. (1991). CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.

Bliss, S. K., Bliss, S. P., Beiting, D. P., Alcaraz, A., & Appleton, J. A. (2007). IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. The Journal of Immunology178(12), 7974-7983.


Availability: In stock

Size Price Qty
25 μg
$70.00
100 μg
$160.00
Additional RM4-5 Formats
Cat.No. Format Starting From
06122-60PE $ 30.00
06122-70PerCP-Cyanine5.5 $ 80.00
06122-77PE-Cyanine7 $ 70.00
06122-40BG Violet 450 $ 75.00
06122-50FITC $ 30.00
06122-87APC-Cyanine7 $ 65.00
06122-80APC $ 65.00