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XAV939



Catalog Number : 2848932

Description

XAV939 is a potent inhibitor of TNKS 1 and 2, which promotes the degradation of Beta-catenin and increases the protein levels of the axin-GSK3Beta complex. It is reported to promote cardiomyogenic development in progenitor cells, inhibits the proliferation of certain carcinoma cell lines, and enhances the induction of cortical interneurons from embryonic stem cells.
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Additional Information

Applications:
FA
Synonyms:
XAV-939, CHEMBL1086580, 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Formulation:
Crystalline solid
Chemical Name:
2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
Molecular Formula:

C14H11F3N2OS

Molecular Weight:
312.3
CAS Number
284028-89-3
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S. W., Ganat, Y. M., Merkle, F. T., ... & Studer, L. (2013). Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell stem cell12(5), 559-572.

Tian, X. H., Hou, W. J., Fang, Y., Fan, J., Tong, H., Bai, S. L., ... & Li, Y. (2013). XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway. J Exp Clin Cancer Res32(100), 9966-32.

Liu, C., & He, X. (2010). Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway. Journal of molecular cell biology2(2), 70-73.


Availability: In stock

Size Price Qty
10mg
$90.00
25mg
$195.00