SB 216763

Grouped product items
SizePrice Qty
10mg
$125.00
50mg
$520.00
Catalog Number : 2800944

description

SB 216763 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3), including the alpha and beta isozymes. It displays neuroprotectant properties and stimulates glycogen synthesis in liver cells. SB 216763 is reported to be used to maintain the undifferentiated state of mouse embryonic stem cells.
product image

Additional Information

Applications:
FA
Synonyms:
SB216763, SB-216763, SCHEMBL30251
Formulation:
Crystalline solid
Chemical Name:
3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
Molecular Formula:

C19H12Cl2N2O2

Molecular Weight:
371.2
CAS Number
280744-09-4
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Gross, E. R., Hsu, A. K., & Gross, G. J. (2008). Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP-and MPTP-dependent mechanism at reperfusion. American Journal of Physiology-Heart and Circulatory Physiology294(3), H1497-H1500.

Coghlan, M. P., Culbert, A. A., Cross, D. A., Corcoran, S. L., Yates, J. W., Pearce, N. J., ... & Holder, J. C. (2000). Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chemistry & biology7(10), 793-803.

Kirby, L. A., Schott, J. T., Noble, B. L., Mendez, D. C., Caseley, P. S., Peterson, S. C., ... & Patel, N. V. (2012). Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.PloS one7(6), e39329.

© BioGems International, Inc. All rights reserved.