SB 216763

Grouped product items
Size	Price	Qty
10mg	$140.00
50mg	$590.00

Catalog Number : 2800944

description

SB 216763 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3), including the alpha and beta isozymes. It displays neuroprotectant properties and stimulates glycogen synthesis in liver cells. SB 216763 is reported to be used to maintain the undifferentiated state of mouse embryonic stem cells.

Additional Information

Applications:	FA
Synonyms:	SB216763, SB-216763, SCHEMBL30251
Formulation:	Crystalline solid
Chemical Name:	3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
Molecular Formula:	C₁₉H₁₂Cl₂N₂O₂
Molecular Weight:	371.2
CAS Number	280744-09-4
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Gross, E. R., Hsu, A. K., & Gross, G. J. (2008). Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP-and MPTP-dependent mechanism at reperfusion. American Journal of Physiology-Heart and Circulatory Physiology, 294(3), H1497-H1500. Coghlan, M. P., Culbert, A. A., Cross, D. A., Corcoran, S. L., Yates, J. W., Pearce, N. J., ... & Holder, J. C. (2000). Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chemistry & biology, 7(10), 793-803. Kirby, L. A., Schott, J. T., Noble, B. L., Mendez, D. C., Caseley, P. S., Peterson, S. C., ... & Patel, N. V. (2012). Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.PloS one, 7(6), e39329.