IWP-4

Grouped product items
SizePrice Qty
1mg
$35.00
10mg
$300.00
Catalog Number : 6861787

description

IWP-4 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.
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Additional Information

Applications:
FA
Synonyms:
Inhibitor of Wnt Production-4
Formulation:
Crystalline solid
Chemical Name:
N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide
Molecular Formula:

C23H20N4O3S3

Molecular Weight:
496.6
CAS Number
686772-17-8
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology5(2), 100-107.

Hudson, J., Titmarsh, D., Hidalgo, A., Wolvetang, E., & Cooper-White, J. (2011). Primitive cardiac cells from human embryonic stem cells. Stem cells and development21(9), 1513-1523.

Bilir, B., Kucuk, O., & Moreno, C. S. (2013). Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med11(1), 280.

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