Thiazovivin
Catalog Number : 1227180
description
Thiazovivin is a selective Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor. It is reported to greatly enhance the efficiency of generating induced pluripotent stem cells and promote the survival of human embryonic stem cells during dissociation. Thiazovivin stabilizes the E-cadherin protein on the cell surface.
Additional Information
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Applications:
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FA
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Synonyms:
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PubChem24336, CHEMBL3184878
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Formulation:
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Crystalline solid
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Chemical Name:
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N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
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Molecular Formula:
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C15H13N5OS |
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Molecular Weight: |
311.4
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CAS Number
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1226056-71-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., ... & Ding, S. (2009). A chemical platform for improved induction of human iPSCs.Nature methods, 6(11), 805-808. Xu, Y., Zhu, X., Hahm, H. S., Wei, W., Hao, E., Hayek, A., & Ding, S. (2010). Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proceedings of the National Academy of Sciences, 107(18), 8129-8134. Mohseni, R., Shoae‐Hassani, A., & Verdi, J. (2015). Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. Cell biology international, 39(5), 515-518. |