Thiazovivin

Grouped product items
SizePrice Qty
1mg
$45.00
10mg
$160.00
Catalog Number : 1227180

description

Thiazovivin is a selective Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor. It is reported to greatly enhance the efficiency of generating induced pluripotent stem cells and promote the survival of human embryonic stem cells during dissociation. Thiazovivin stabilizes the E-cadherin protein on the cell surface.
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Additional Information

Applications:
FA
Synonyms:
PubChem24336, CHEMBL3184878
Formulation:
Crystalline solid
Chemical Name:
N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
Molecular Formula:

C15H13N5OS

Molecular Weight:
311.4
CAS Number
1226056-71-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., ... & Ding, S. (2009). A chemical platform for improved induction of human iPSCs.Nature methods6(11), 805-808.

Xu, Y., Zhu, X., Hahm, H. S., Wei, W., Hao, E., Hayek, A., & Ding, S. (2010). Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proceedings of the National Academy of Sciences107(18), 8129-8134.

Mohseni, R., Shoae‐Hassani, A., & Verdi, J. (2015). Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. Cell biology international39(5), 515-518.

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