CD 437
Catalog Number : 1256011
description
CD 437 is a synthetic retinoid that functions as a selective agonist of the retinoic acid receptor. It is reported to induce apoptosis and arrest cell cycle activity in a variety of cancer lines.
Additional Information
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Applications:
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FA
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Synonyms:
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AHPN, CD437, O-Desmethyl Adapalene, 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid
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Formulation:
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Crystalline solid
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Chemical Name:
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6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid
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Molecular Formula:
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C27H26O3 |
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Molecular Weight: |
398.5
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CAS Number
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125316-60-1
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Sun, S. Y., Yue, P., & Lotan, R. (2000). Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells. Oncogene, 19(39), 4513-4522. Li, Y., Lin, B., Agadir, A., Liu, R., Dawson, M. I., Reed, J. C., ... & Zhang, X. K. (1998). Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Molecular and cellular biology, 18(8), 4719-4731. Wang, W., Yang, J., Liu, H., Lu, D., Chen, X., Zenonos, Z., ... & Liu, P. (2011). Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.Proceedings of the National Academy of Sciences, 108(45), 18283-18288. |