CD 437

Grouped product items
SizePrice Qty
10mg
$105.00
50mg
$435.00
Catalog Number : 1256011

description

CD 437 is a synthetic retinoid that functions as a selective agonist of the retinoic acid receptor. It is reported to induce apoptosis and arrest cell cycle activity in a variety of cancer lines.
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Additional Information

Applications:
FA
Synonyms:
AHPN, CD437, O-Desmethyl Adapalene, 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid
Formulation:
Crystalline solid
Chemical Name:
6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid
Molecular Formula:

C27H26O3

Molecular Weight:
398.5
CAS Number
125316-60-1
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Sun, S. Y., Yue, P., & Lotan, R. (2000). Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells. Oncogene19(39), 4513-4522.

Li, Y., Lin, B., Agadir, A., Liu, R., Dawson, M. I., Reed, J. C., ... & Zhang, X. K. (1998). Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Molecular and cellular biology18(8), 4719-4731.

Wang, W., Yang, J., Liu, H., Lu, D., Chen, X., Zenonos, Z., ... & Liu, P. (2011). Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.Proceedings of the National Academy of Sciences108(45), 18283-18288.

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