SB 203580 hydrochloride

Grouped product items
SizePrice Qty
10mg
$190.00
25mg
$450.00
Catalog Number : 8698538

description

SB 203580 is a p38 specific inhibitor that prevents the downstream activation of heat shock protein 27 and MAP kinase-activated protein kinase 2 (MAPKAPK2). It can have anti-proliferative activity on cytokine-activated lymphocytes and is reported to be used to enhance cardiomyocyte differentiation. The hydrochloride form is more soluble in organic solvents than the standard formulation.
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Additional Information

Applications:
FA
Synonyms:
SB203580 hydrochloride, PubChem24446, SCHEMBL4890447, HY-10256A
Formulation:
Crystalline solid
Chemical Name:
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine;hydrochloride
Molecular Formula:

C21H16FN3OS HCl

Molecular Weight:
413.9
CAS Number
869185-85-3
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Lali, F. V., Hunt, A. E., Turner, S. J., & Foxwell, B. M. (2000). The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. Journal of Biological Chemistry275(10), 7395-7402.

Barancik, M., Htun, P., Strohm, C., Kilian, S., & Schaper, W. (2000). Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death.Journal of cardiovascular pharmacology35(3), 474-483.

Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., & Marber, M. S. (2001). Antiischemic Effects of SB203580 Are Mediated Through the Inhibition of p38α Mitogen-Activated Protein Kinase Evidence From Ectopic Expression of an Inhibition-Resistant Kinase. Circulation research89(9), 750-752.

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