Reversine

Grouped product items
SizePrice Qty
5mg
$140.00
25mg
$540.00
Catalog Number : 6563252

description

Reversine is a potent adenosine A3 receptor, MEK1, and Aurora B kinase inhibitor. It is reported to be used to de-differentiate myoblasts to stem cell progenitors with adipogenic and osteogenic potential. Reversine is also used to selectively induce cell death in cancer cells
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Additional Information

Applications:
FA
Synonyms:
2-(4-Morpholinoanilino)-6-cyclohexylaminopurine, CHEMBL188343
Formulation:
Crystalline solid
Chemical Name:
6-N-cyclohexyl-2-N-(4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
Molecular Formula:

C21H27N7O

Molecular Weight:
393.5
CAS Number
656820-32-5
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Chen, S., Takanashi, S., Zhang, Q., Xiong, W., Zhu, S., Peters, E. C., ... & Schultz, P. G. (2007). Reversine increases the plasticity of lineage-committed mammalian cells. Proceedings of the National Academy of Sciences104(25), 10482-10487.

D'Alise, A. M., Amabile, G., Iovino, M., Di Giorgio, F. P., Bartiromo, M., Sessa, F., ... & Cortese, R. (2008). Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Molecular cancer therapeutics7(5), 1140-1149.

Anastasia, L., Sampaolesi, M., Papini, N., Oleari, D., Lamorte, G., Tringali, C., ... & Venerando, B. (2006). Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle. Cell Death & Differentiation13(12), 2042-2051.

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