Reversine

Grouped product items
Size	Price	Qty
5mg	$160.00
25mg	$615.00

Catalog Number : 6563252

description

Reversine is a potent adenosine A3 receptor, MEK1, and Aurora B kinase inhibitor. It is reported to be used to de-differentiate myoblasts to stem cell progenitors with adipogenic and osteogenic potential. Reversine is also used to selectively induce cell death in cancer cells

Additional Information

Applications:	FA
Synonyms:	2-(4-Morpholinoanilino)-6-cyclohexylaminopurine, CHEMBL188343
Formulation:	Crystalline solid
Chemical Name:	6-N-cyclohexyl-2-N-(4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
Molecular Formula:	C₂₁H₂₇N₇O
Molecular Weight:	393.5
CAS Number	656820-32-5
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Chen, S., Takanashi, S., Zhang, Q., Xiong, W., Zhu, S., Peters, E. C., ... & Schultz, P. G. (2007). Reversine increases the plasticity of lineage-committed mammalian cells. Proceedings of the National Academy of Sciences, 104(25), 10482-10487. D'Alise, A. M., Amabile, G., Iovino, M., Di Giorgio, F. P., Bartiromo, M., Sessa, F., ... & Cortese, R. (2008). Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Molecular cancer therapeutics, 7(5), 1140-1149. Anastasia, L., Sampaolesi, M., Papini, N., Oleari, D., Lamorte, G., Tringali, C., ... & Venerando, B. (2006). Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle. Cell Death & Differentiation, 13(12), 2042-2051.