LY-411575

Grouped product items
Size Price Qty
5mg
$90.00
25mg
$375.00
Catalog Number : 2095768

description

LY-411575 is a potent and selective inhibitor of y-secretase, which is involved in APP proteolysis. Via this inhibition, it also blocks Notch activation. LY-411575 is reported to have anti-cancer applications and is capable of promoting goblet cell differentiation in mouse organoids.

Additional Information

Applications:
FA
Synonyms:
LY 411575, LY411575, Semagacestat
Formulation:
Crystalline solid
Chemical Name:
(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
Molecular Formula:

C26H23F2N3O4

Molecular Weight:
479.5
CAS Number
209984-57-6
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Wong, G. T., Manfra, D., Poulet, F. M., Zhang, Q., Josien, H., Bara, T., ... & Parker, E. M. (2004). Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. Journal of Biological Chemistry279(13), 12876-12882.

Chen, F., Eckman, E. A., & Eckman, C. B. (2006). Reductions in levels of the Alzheimer’s amyloid β peptide after oral administration of ginsenosides. The FASEB Journal20(8), 1269-1271.

Curry, C. L., Reed, L. L., Golde, T. E., Miele, L., Nickoloff, B. J., & Foreman, K. E. (2005). Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene24(42), 6333-6344.

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