Losartan potassium
Catalog Number : 1249980
description
Losartan potassium is a selective angiotensin II receptor type 1 (AT1) antagonist with antihypertensive properties. It is metabolized to produce the 5-carboxylic acid metabolite (EXP3174) and is reported to lower blood pressure. It is currently being researched as a potential treatment for COVID-19 for its potential to mitigate or possibly attenuate the symptoms of COVID-19.
Additional Information
|
Applications:
|
FA
|
|
Synonyms:
|
Cozaar, MK 954, MK-954, DuP-753
|
|
Formulation:
|
Crystalline solid
|
|
Chemical Name:
|
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
|
|
Molecular Formula:
|
C22H22ClN6O K |
|
Molecular Weight: |
461.0
|
|
CAS Number
|
124750-99-8
|
|
Purity:
|
98%
|
|
Storage Conditions:
|
Product should be kept at -20°C.
|
|
References:
|
Goa, K. L., & Wagstaff, A. J. (1996). Losartan potassium. Drugs, 51(5), 820-845. Sica, D. A., Gehr, T. W., & Ghosh, S. (2005). Clinical pharmacokinetics of losartan. Clinical pharmacokinetics, 44(8), 797-814. Zeinalian, M., Salari-Jazi, A., Jannesari, A., & Khanahmad, H. (2020). A potential protective role of losartan against coronavirus-induced lung damage. Infection Control & Hospital Epidemiology, 1-2. |