GDC-0068
description
Additional Information
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Applications:
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FA
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Synonyms:
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RG-7440, Ipatasertib
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Formulation:
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Crystalline solid
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Chemical Name:
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(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
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Molecular Formula:
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C24H32CIN5O2 |
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Molecular Weight: |
458.0
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CAS Number
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1001264-89-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Lin, J., Sampath, D., Nannini, M. A., Lee, B. B., Degtyarev, M., Oeh, J., ... & Lee, L. B. (2013). Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clinical Cancer Research, 19(7), 1760-1772. Yan, Y., Serra, V., Prudkin, L., Scaltriti, M., Murli, S., Rodríguez, O., ... & Wagle, M. C. (2013). Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068. Clinical Cancer Research, 19(24), 6976-6986. Blake, J. F., Xu, R., Bencsik, J. R., Xiao, D., Kallan, N. C., Schlachter, S., ... & Gloor, S. L. (2012). Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. Journal of medicinal chemistry, 55(18), 8110-8127. |