GDC-0068

Grouped product items
SizePrice Qty
5mg
$225.00
10mg
$400.00
Catalog Number : 1008962

description

GDC-0068 is a potent and selective pan-AKT inhibitor that targets Akt1, Akt2, and Akt3 over other kinases. It inhibits cell cycle progression and exhibits antitumor properties, reducing the viability of cancer cell lines.
product image

Additional Information

Applications:
FA
Synonyms:
RG-7440, Ipatasertib
Formulation:
Crystalline solid
Chemical Name:
(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
Molecular Formula:

C24H32CIN5O2

Molecular Weight:
458.0
CAS Number
1001264-89-6
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Lin, J., Sampath, D., Nannini, M. A., Lee, B. B., Degtyarev, M., Oeh, J., ... & Lee, L. B. (2013). Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clinical Cancer Research19(7), 1760-1772.

Yan, Y., Serra, V., Prudkin, L., Scaltriti, M., Murli, S., Rodríguez, O., ... & Wagle, M. C. (2013). Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068. Clinical Cancer Research19(24), 6976-6986.

Blake, J. F., Xu, R., Bencsik, J. R., Xiao, D., Kallan, N. C., Schlachter, S., ... & Gloor, S. L. (2012). Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. Journal of medicinal chemistry55(18), 8110-8127.

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