ALK5 Inhibitor (RepSox)

Grouped product items
SizePrice Qty
5mg
$80.00
10mg
$140.00
Catalog Number : 4463325

description

The ALK5 inhibitor selectively inhibits TGF-Beta receptor signaling, useful for enhancing the efficiency of cellular reprogramming. It is also reported to induce the differentiation of pancreatic progenitor cells into insulin-producing cells.
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Additional Information

Applications:
FA
Synonyms:
RepSox, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, ALK5 Inhibitor II, E616452
Formulation:
Crystalline solid
Chemical Name:
2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Molecular Formula:

C17H13N5

Molecular Weight:
287.3
CAS Number
446859-33-2
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Woltjen, K., & Stanford, W. L. (2009). Inhibition of Tgf-β Signaling Improves Mouse Fibroblast Reprogramming. Cell stem cell5(5), 457-458.

Larsen, D. M. (2013). Evaluation of the TGF-beta inhibitor RepSox on the expression of pluripotency pathways in murine and bovine cells. UTAH STATE UNIVERSITY.

Jajosky, A. N., Coad, J. E., Vos, J. A., Martin, K. H., Senft, J. R., Wenger, S. L., & Gibson, L. F. (2014). RepSox Slows Decay of CD34+ Acute Myeloid Leukemia Cells and Decreases T Cell Immunoglobulin Mucin-3 Expression.Stem cells translational medicine3(7), 836.

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