G-15
Catalog Number : 1160560
description
G-15 is a selective antagonist of GPR30 receptor, an estradiol binding receptor that contributes to both uterine and neurological responses. G-15 is reported to oppose the physiological effects of estrogen and inhibit calcium mobilization in vitro.
Additional Information
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Applications:
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FA
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Synonyms:
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AC1LMJHT, CTK8E6722, ZINC00871833
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Formulation:
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Crystalline solid
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Chemical Name:
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(3aR,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
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Molecular Formula:
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C19H16BrNO2 |
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Molecular Weight: |
370.2
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CAS Number
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1161002-05-6
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Dennis, M. K., Burai, R., Ramesh, C., Petrie, W. K., Alcon, S. N., Nayak, T. K., ... & Prossnitz, E. R. (2009). In vivo effects of a GPR30 antagonist. Nature chemical biology, 5(6), 421-427. Ariazi, E. A., Brailoiu, E., Yerrum, S., Shupp, H. A., Slifker, M. J., Cunliffe, H. E., ... & Jordan, V. C. (2010). The G protein–coupled receptor GPR30 inhibits proliferation of estrogen receptor–positive breast cancer cells. Cancer research,70(3), 1184-1194. Hammond, R., & Gibbs, R. B. (2011). GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance. Brain research, 1379, 53-60. |