G-15

Grouped product items
SizePrice Qty
1mg
$60.00
25mg
$350.00
Catalog Number : 1160560

description

G-15 is a selective antagonist of GPR30 receptor, an estradiol binding receptor that contributes to both uterine and neurological responses. G-15 is reported to oppose the physiological effects of estrogen and inhibit calcium mobilization in vitro.
product image

Additional Information

Applications:
FA
Synonyms:
AC1LMJHT, CTK8E6722, ZINC00871833
Formulation:
Crystalline solid
Chemical Name:
(3aR,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Molecular Formula:

C19H16BrNO2

Molecular Weight:
370.2
CAS Number
1161002-05-6
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Dennis, M. K., Burai, R., Ramesh, C., Petrie, W. K., Alcon, S. N., Nayak, T. K., ... & Prossnitz, E. R. (2009). In vivo effects of a GPR30 antagonist. Nature chemical biology5(6), 421-427.

Ariazi, E. A., Brailoiu, E., Yerrum, S., Shupp, H. A., Slifker, M. J., Cunliffe, H. E., ... & Jordan, V. C. (2010). The G protein–coupled receptor GPR30 inhibits proliferation of estrogen receptor–positive breast cancer cells. Cancer research,70(3), 1184-1194.

Hammond, R., & Gibbs, R. B. (2011). GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance. Brain research1379, 53-60.

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