T 0901317

Grouped product items
SizePrice Qty
10mg
$30.00
50mg
$125.00
Catalog Number : 2935595

description

T 0901317 is a potent agonist for the high affinity liver X receptor, which up-regulates ABC1 gene expression. It is reported that it can be used to lower cholesterol levels in serum and liver, to suppress the proliferation of breast and prostate cancer cells, and to decrease amyloid beta production.
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Additional Information

Applications:
FA
Synonyms:
T-0901317, T0901317
Formulation:
Crystalline solid
Chemical Name:
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Molecular Formula:

C17H12F9NO3S

Molecular Weight:
481.3
CAS Number
293754-55-9
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., ... & Lazo, J. S. (2005). The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. Journal of Biological Chemistry280(6), 4079-4088.

Mitro, N., Vargas, L., Romeo, R., Koder, A., & Saez, E. (2007). T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS letters,581(9), 1721-1726.

Chisholm, J. W., Hong, J., Mills, S. A., & Lawn, R. M. (2003). The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Journal of lipid research44(11), 2039-2048.

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