L-755,507
Catalog Number : 1594312
description
L-755,507 is a potent and selective β3 adrenergic receptor partial agonist. It is reported to enhance CRISRP-mediated homology-directed efficiency 2-3 fold for large fragments and around 9-fold for point mutations. L-755,507 stimulates lipolysis in rhesus adipocytes and increases the metabolic rate after administration.
Additional Information
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Applications:
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FA
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Synonyms:
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L-755507, L 755507, L755507
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Formulation:
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Crystalline solid
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Chemical Name:
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1-hexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]urea
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Molecular Formula:
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C30H40N4O6S |
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Molecular Weight: |
584.7
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CAS Number
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159182-43-1
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Parmee, E. R., Ok, H. O., Candelore, M. R., Tota, L., Deng, L., Strader, C. D., ... & Weber, A. E. (1998). Discovery of L-755,507: a subnanomolar human β 3 adrenergic receptor agonist. Bioorganic & medicinal chemistry letters, 8(9), 1107-1112. Fisher, M. H., Amend, A. M., Bach, T. J., Barker, J. M., Brady, E. J., Candelore, M. R., ... & Forrest, M. J. (1998). A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. Journal of Clinical Investigation, 101(11), 2387. Yu, C., Liu, Y., Ma, T., Liu, K., Xu, S., Zhang, Y., ... & Qi, L. S. (2015). Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell stem cell, 16(2), 142-147.
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