L-755,507

Grouped product items
SizePrice Qty
10mg
$165.00
50mg
$715.00
Catalog Number : 1594312

description

L-755,507 is a potent and selective β3 adrenergic receptor partial agonist. It is reported to enhance CRISRP-mediated homology-directed efficiency 2-3 fold for large fragments and around 9-fold for point mutations. L-755,507 stimulates lipolysis in rhesus adipocytes and increases the metabolic rate after administration.
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Additional Information

Applications:
FA
Synonyms:
L-755507, L 755507, L755507
Formulation:
Crystalline solid
Chemical Name:
1-hexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]urea
Molecular Formula:

C30H40N4O6S

Molecular Weight:
584.7
CAS Number
159182-43-1
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Parmee, E. R., Ok, H. O., Candelore, M. R., Tota, L., Deng, L., Strader, C. D., ... & Weber, A. E. (1998). Discovery of L-755,507: a subnanomolar human β 3 adrenergic receptor agonist. Bioorganic & medicinal chemistry letters8(9), 1107-1112.

Fisher, M. H., Amend, A. M., Bach, T. J., Barker, J. M., Brady, E. J., Candelore, M. R., ... & Forrest, M. J. (1998). A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. Journal of Clinical Investigation101(11), 2387.

Yu, C., Liu, Y., Ma, T., Liu, K., Xu, S., Zhang, Y., ... & Qi, L. S. (2015). Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell stem cell16(2), 142-147.

 

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