Diazoxide

Grouped product items
SizePrice Qty
100mg
$55.00
Catalog Number : 3649874

description

Diazoxide is a potassium channel activator and vasodilator. It is reported to inhibit the secretion of insulin by the opening of the ATP-sensitive potassium channel of beta cells of the pancreas and to block the desensitization of AMPA receptors.
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Additional Information

Applications:
FA
Synonyms:
Proglycem, Hyperstat, NSC 64198, Mutabase
Formulation:
Crystalline solid
Chemical Name:
7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide
Molecular Formula:

C8H7ClN2O2S

Molecular Weight:
230.7
CAS Number
364-98-7
Purity:
≥99%
Storage Conditions:
Product should be kept at -20°C.
References:

Garlid, K. D., Paucek, P., Yarov-Yarovoy, V., Murray, H. N., Darbenzio, R. B., D’Alonzo, A. J., ... & Grover, G. J. (1997). Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels: possible mechanism of cardioprotection. Circulation research81(6), 1072-1082.

NESTLER, J. E., BARLASCINI, C. O., MATT, D. W., STEINGOLD, K. A., PLYMATE, S. R., CLORE, J. N., & BLACKARD, W. G. (1989). Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism68(6), 1027-1032.

Korge, P., Honda, H. M., & Weiss, J. N. (2002). Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning. Proceedings of the National Academy of Sciences99(5), 3312-3317.

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