Calcitriol

Grouped product items
SizePrice Qty
1mg
$75.00
10mg
$525.00
Catalog Number : 3220632

description

Calcitriol is the hormonally active metabolite of vitamin D with the addition of three hydroxyl groups. Its main biological effect is to increase the mineralization of bone and the uptake of calcium from the gut into the blood. Calcitriol activates osteoclasts by causing osteoblasts to release Receptor activator of nuclear factor kappa-B ligand (RANKL). It is also reported to exhibit antitumor properties by inhibiting the proliferation of a variety of carcinomas and leukemia cells.
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Additional Information

Applications:
FA
Synonyms:
Bocatriol, Calcijex, Decostriol, Osteotriol, Rocaltrol, Tirocal, D3, 1,25-Dihydroxyvitamin
Formulation:
Crystalline solid
Chemical Name:
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Molecular Formula:

C27H44O3

Molecular Weight:
416.6
CAS Number
32222-06-3
Purity:
≥97%
Storage Conditions:
Product should be kept at -20°C.
References:

Rigby, W. F., Stacy, T., & Fanger, M. W. (1984). Inhibition of T lymphocyte mitogenesis by 1, 25-dihydroxyvitamin D3 (calcitriol). Journal of Clinical Investigation74(4), 1451.

Gross, C., Stamey, T., Hancock, S., & Feldman, D. (1998). Treatment of early recurrent prostate cancer with 1, 25-dihydroxyvitamin D3 (calcitriol). The Journal of urology159(6), 2035-2040.

Daniel, C., Sartory, N. A., Zahn, N., Radeke, H. H., & Stein, J. M. (2008). Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. Journal of Pharmacology and Experimental Therapeutics324(1), 23-33.

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