2’3’-cGAMP

Grouped product items
SizePrice Qty
500ug
$275.00
1mg
$525.00
Catalog Number : 1446640

description

2’3’-cGAMP binds to STING (stimulator of IFN genes) and functions as an endognous second messenger to activate the innate immune system. It is produced by the cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation.
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Additional Information

Applications:
FA
Synonyms:
cGAMP, cyclic GMP-AMP, cyclic guanosine monophosphate-adenosine monophosphate, Cyclic guanosine monophosphate-adenosine monophosphate
Formulation:
Crystalline solid
Chemical Name:
2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine
Molecular Formula:

C20H24N10O13P2

Molecular Weight:
674.4
CAS Number
1441190-66-4
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Li, X. D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013). Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science341(6152), 1390-1394.

Kranzusch, P. J., Wilson, S. C., Lee, A. S., Berger, J. M., Doudna, J. A., & Vance, R. E. (2015). Ancient origin of cGAS-STING reveals mechanism of universal 2′, 3′ cGAMP signaling. Molecular cell59(6), 891-903.

Gao, D., Wu, J., Wu, Y. T., Du, F., Aroh, C., Yan, N., ... & Chen, Z. J. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science341(6148), 903-906.

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