2’3’-cGAMP
Catalog Number : 1446640
description
2’3’-cGAMP binds to STING (stimulator of IFN genes) and functions as an endognous second messenger to activate the innate immune system. It is produced by the cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation.
Additional Information
|
Applications:
|
FA
|
|
Synonyms:
|
cGAMP, cyclic GMP-AMP, cyclic guanosine monophosphate-adenosine monophosphate, Cyclic guanosine monophosphate-adenosine monophosphate
|
|
Formulation:
|
Crystalline solid
|
|
Chemical Name:
|
2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine
|
|
Molecular Formula:
|
C20H24N10O13P2 |
|
Molecular Weight: |
674.4
|
|
CAS Number
|
1441190-66-4
|
|
Purity:
|
≥98%
|
|
Storage Conditions:
|
Product should be kept at -20°C.
|
|
References:
|
Li, X. D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013). Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science, 341(6152), 1390-1394. Kranzusch, P. J., Wilson, S. C., Lee, A. S., Berger, J. M., Doudna, J. A., & Vance, R. E. (2015). Ancient origin of cGAS-STING reveals mechanism of universal 2′, 3′ cGAMP signaling. Molecular cell, 59(6), 891-903. Gao, D., Wu, J., Wu, Y. T., Du, F., Aroh, C., Yan, N., ... & Chen, Z. J. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science, 341(6148), 903-906. |