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10058-F4



Catalog Number : 4035521

Description

10058-F4 is a cell-permeable thiazolidinone inhibitor of c-Myc and Max, which induces cell cycle arrest and apoptosis. It also inhibits N-Myc, inducing apoptosis in cells that overexpress N-Myc. It is reported to inhibit the growth of tumor cells.
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Additional Information

Applications:
FA
Synonyms:
c-Myc Inhibitor
Formulation:
Crystalline solid
Chemical Name:
(5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
Molecular Formula:

C12H11NOS2

Molecular Weight:
249.4
CAS Number
403811-55-2
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Huang, M. J., Cheng, Y. C., Liu, C. R., Lin, S., & Liu, H. E. (2006). A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Experimental hematology34(11), 1480-1489.

Guo, J., Parise, R. A., Joseph, E., Egorin, M. J., Lazo, J. S., Prochownik, E. V., & Eiseman, J. L. (2009). Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z, E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer chemotherapy and pharmacology63(4), 615-625.

Wang, H., Teriete, P., Hu, A., Raveendra-Panickar, D., Pendelton, K., Lazo, J. S., ... & Arsenian-Henriksson, M. (2015). Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids. Oncotarget6(32), 32380.


Availability: In stock

Size Price Qty
10mg
$95.00
50mg
$300.00