10058-F4

Grouped product items
Size	Price	Qty
10mg	$105.00
50mg	$340.00

Catalog Number : 4035521

description

10058-F4 is a cell-permeable thiazolidinone inhibitor of c-Myc and Max, which induces cell cycle arrest and apoptosis. It also inhibits N-Myc, inducing apoptosis in cells that overexpress N-Myc. It is reported to inhibit the growth of tumor cells.

Additional Information

Applications:	FA
Synonyms:	c-Myc Inhibitor
Formulation:	Crystalline solid
Chemical Name:	(5E)-5-[(4-ethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
Molecular Formula:	C₁₂H₁₁NOS₂
Molecular Weight:	249.4
CAS Number	403811-55-2
Purity:	≥95%
Storage Conditions:	Product should be kept at -20°C.
References:	Huang, M. J., Cheng, Y. C., Liu, C. R., Lin, S., & Liu, H. E. (2006). A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Experimental hematology, 34(11), 1480-1489. Guo, J., Parise, R. A., Joseph, E., Egorin, M. J., Lazo, J. S., Prochownik, E. V., & Eiseman, J. L. (2009). Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z, E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer chemotherapy and pharmacology, 63(4), 615-625. Wang, H., Teriete, P., Hu, A., Raveendra-Panickar, D., Pendelton, K., Lazo, J. S., ... & Arsenian-Henriksson, M. (2015). Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids. Oncotarget, 6(32), 32380.