KRN 7000
Catalog Number : 1584771
description
KRN 7000 is a potent activator of NKT cells and CD1d ligand that was originally isolated from the murine sponge Agelas mauritianus. It exhibits immunostimulant and anti-tumor properties and is also reported to protect against LPS-induced shock.
Additional Information
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Applications:
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FA
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Synonyms:
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KRN7000, alpha-GalCer, alpha-Galactosylceramide
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Formulation:
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Crystalline solid
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Chemical Name:
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N-[(2S,3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide
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Molecular Formula:
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C50H99NO9 |
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Molecular Weight: |
858.3
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CAS Number
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158021-47-7
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Purity:
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≥96%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Banchet-Cadeddu, A., Hénon, E., Dauchez, M., Renault, J. H., Monneaux, F., & Haudrechy, A. (2011). The stimulating adventure of KRN 7000. Organic & biomolecular chemistry, 9(9), 3080-3104. Kobayashi, E., Motoki, K., Uchida, T., Fukushima, H., & Koezuka, Y. (1995). KRN7000, a novel immunomodulator, and its antitumor activities. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 7(10-11), 529-534. Hayakawa, Y., Rovero, S., Forni, G., & Smyth, M. J. (2003). α-Galactosylceramide (KRN7000) suppression of chemical-and oncogene-dependent carcinogenesis. Proceedings of the National Academy of Sciences, 100(16), 9464-9469. |