Recombinant laminin-221 (BG iMatrix-221)
description
BG iMatrix 221 is a chemically defined, animal-free, and xeno-free laminin-221 E8 fragment. Laminin-332 primarily binds to the cell surface transmembrane receptors integrin α7X2β1. It can be used as a substrate for the proliferation and differentiation of cardiomyocytes and skeletal muscles.
The 350ug size is supplied as 2x175ug vials. The 1050ug size is supplied as 6x175ug vials.
Additional Information
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Applications:
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Cell Culture
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| Research Interest: | Stem Cell Research |
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| Cell Type: | Stem Cells |
| Application: | Cell Culture |
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Application Notes:
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Formulation:
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0.5mg/mL in PBS(-).
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References:
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1. Nishiuchi, R., Takagi, J., Hayashi, M., Ido, H., Yagi, Y., Sanzen N., Tsuji T., Yamada M., & Sekiguchi K. (2006). Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin–integrin interactions using recombinant α3β1, α6β1, α7β1 and α6β4 integrins. Matrix Biology, 25(3), 189-197. 2. Taniguchi, Y., Ido, H., Sanzen, N., Sato-Nishiuchi, R., Futaki, S., & Sekiguchi, K. (2009). The C-terminal Region of Laminin β Chains Modulates the Integrin Binding Affinities of Laminins. The Journal of Biological Chemistry, 284(12), 7820-31. 3. Israeli-Rosenberg, S., Manso, A. M., Okada, H., & Ross, R. (2014). Integrins and Integrin-Associated Proteins in the Cardiac Myocyte. Circular Research, 114(3), 572-586. |