Recombinant laminin-511 (BG iMatrix-511 Silk)

Grouped product items
Size Price Qty
350 ug
Catalog Number : RL511S


BG iMatrix 511 Silk is a chemically defined, animal-free, and xeno-free laminin-511 E8 fragment. Laminin-511 is well known to bind to integrin α6ß1, which is located on the cell surface and acts as a substrate for stem cell culture media for various cell types including ESCs and iPSCs. Recombinant laminin-511 E8 fragments are truncated, functional forms of laminin composed of the C-terminal regions of the alpha, beta, and gamma chains. Laminin-511 E8 (150 kDa) retains the full capability for binding to alpha 6 beta 1 integrin. 

The 350ug size is supplied as 2x175ug vials. The 1050ug size is supplied as 6x175ug vials.    

Review the Data Sheet and Product Brochure for more details. 

Additional Information

Cell Culture
Research Interest: Stem Cell Research
Cell Type: Stem Cells
Application: Cell Culture
Application Notes:
0.5mg/mL in PBS(-).

Taniguchi, Y., Ido, H., Sanzen, N., Hayashi, M., Sato-Nishiuchi, R., Futaki, S., & Sekiguchi, K. . The C-terminal region of laminin β chains modulates the integrin binding affinities of laminins. Journal of Biological Chemistry, 284(12), 7820-7831, (2009)

Miyazaki, T., Futaki, S., Suemori, H., Taniguchi, Y., Yamada, M., Kawasaki, M., Hayashi, M., Kumagai, H., Nakatsuji, N., Sekiguchi, K., & Kawase, E. . Laminin E8 fragment support efficient adhesion and expansion of dissociated human pluripotent stem cells. Nature communications, 3(1236), 1-10, (2012)

Burridge, P. W., Matsa, E., Shukla, P., Lin, Z. C., Churko, J. M., Ebert, A. D., Lan, F., Diecke, S., Huber, B., Mordwinkin, N. M., Plews, J. R., Abilez, O. J., Cui, B., Gold, J. D., & Wu, J. C. . Chemically defined generation of human cardiomyocytes. Nature methods, 11(8), 855-860, (2014)

Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichisaka, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., Yoshida, Y., Toyoda, T., Osafune, K., Sekiguchi, K., & Yamanaka, S. . A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells. Scientific reports, 4(3594), 1-7, (2014)

Takayama, K., Mitani, S., Nagamoto, Y., Sakurai, F., Tachibana, M., Taniguchi, Y., Sekiguchi, K., Mizuguchi, H.. Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells. Biochemical and biophysical research communications, 474(1), 91-96, (2016)

Musah, S., Dimitrakakis, N., Camacho, D. M., Church, G. M., Ingber, D. E.. Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a lomerulus Chip. Nature protocols, 13(7), 1662, (2018)


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