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9-cis-Retinoic acid



Catalog Number : 5300380

Description

9-cis-Retinoic acid is a potent activator of all isoforms of retinoic acid receptor and the retinoid X receptor, which act as transcription factors that regulate the growth and differentiation of normal and malignant cells.. It is reported to promote oligodendrocyte precursor cell differentiation and myelination and to also inhibit the synthesis of fatty acids and sterols in hepatocytes.
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Additional Information

Applications
FA
Synonyms:
Alitretinoin, 9-cis-Tretinoin, Panretin
Formulation:
Crystalline solid
Chemical Name:
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Molecular Formula:

C9H14N4O5

Molecular Weight:
258.2
CAS Number
5300-03-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992). 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell68(2), 397-406.

Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., ... & Grippo, J. F. (1992). 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα.

MacDonald, P. N., Dowd, D. R., Nakajima, S., Galligan, M. A., Reeder, M. C., Haussler, C. A., ... & Haussler, M. R. (1993). Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1, 25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene. Molecular and cellular biology13(9), 5907-5917.


Availability: In stock

Size Price Qty
1mg
$40.00
5mg
$105.00